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Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli
Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli
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机译:抗体,抗体片段和抗体片段融合分子在大肠杆菌中的细胞质表达
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摘要
Prodn. of recombinant antibodies (Ab), Ab fragments or Ab fragment/enzyme fusion proteins, where the enzyme is a cytoplasmic mammalian or E. coli enzyme, is effected using a thioredoxinreductase deficient E. coli strain, the expression prods. being isolated from the cytoplasm. Also claimed are: (1) Ab fragment/enzyme fusion protein in which the enzyme is E. coli beta -glucuronidase; and (2) gene encoding the fusion protein of (1).
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