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New taxoids, their preparation and pharmaceutical preparations containing these taxoids
New taxoids, their preparation and pharmaceutical preparations containing these taxoids
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机译:新的类紫杉醇,其制剂以及含有这些类紫杉醇的药物制剂
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摘要
New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical, RSUB1 /SUBrepresents a benzoyl radical or a radical of formula RSUB2/SUB-O-CO- in which RSUB2 /SUBrepresents an optionally substituted alkyl radical, an alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical. The new products of general formula (I) have a remarkable antitumor activity.
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机译:通式(I)的新的类紫杉醇,它们的制备和含有它们的药物组合物。在通式(I)中,Ar表示芳基,R表示氢原子或乙酰基,烷氧基乙酰基或烷基,R SUB 1表示苯甲酰基或式R SUB 2的基团 SUB> -O-CO-,其中R 2 SUB>表示任选取代的烷基,烯基,炔基,环烷基,环烯基,双环烷基,苯基或杂环基。通式(I)的新产品具有显着的抗肿瘤活性。
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