STRUCTURES IN SOLUTION AND IN THE CRYSTAL OF THE ACTIVE CENTER MMP-13 AND THEIR APPLICATION

摘要

The present invention relates to the three-dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the structure of MMP-13 to rationally design or identify compounds or molecules that inhibit or increase MMP-13 activity, and (ii) compounds identified using these methods. The international application was published together with an international search report.