A METHOD FOR ARRESTING OR REDUCING THE ADVANCEMENT OF FOLLICULAR LYMPHOMA AND COMPOSITIONS FOR ITS REALIZATION

摘要

1. A method for arresting or reducing the advancement, severity or effects of follicular lymphoma comprising the administration to a subject of an effective amount of a composition, which inhibits the interaction between LT- and its receptor. 2. The method of claim 1, wherein said composition is selected from the group of a soluble LT-beta receptor, anti-LT-beta antibodies and anti-LT-beta-R antibodies. 3. The method of claim 2, wherein the composition comprises a soluble LT-beta-R receptor. 4. The method of claim 1, wherein the subject is a mammal. 5. The method of claim 4 wherein the subject is a human. 6. The method according to claim 3, wherein the soluble lymphotoxin-beta receptor comprises a ligand binding domain that can selectively bind to a surface LT ligand. 7. The method according to claim 6, wherein the LT-beta-receptor comprises a human immunoglobulin FC domain. 8. The method according to claim 2, wherein the composition comprises a monoclonal antibody directed against and LT-beta-receptor. 9. The method of claim 8, wherein the monoclonal antibody is humanized or chimeric. 10. The method of claim 1, further comprising the administration to said subject of at least one chemotherapeutic agent. 11. The method of claim 1 comprising the administration to said subject of radiation treatments. 12. A composition for the treatment of a subject having follicular lymphoma, which blocks the interaction of LT-beta with its receptor.