CARBAM CONNECTIONS FOR USE IN THE PREVENTION OR TREATMENT OF NEUROPATHIC PAIN AND HISTAMINE HEADACHE AND HEADACHE ASSOCIATED WITH MIGRAINE

摘要

The present invention relates to a method of preventing or treating neuropathic pain and histamine headache and migraine-related headache, comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of formula (I) substantially free of other enantiomers, or an enantiomeric mixture where the enantiomer of formula (I) is predominant (see formula), where phenyl is substituted with one to five substituents X, which are halogen atoms independently selected from the group consisting of ora, chlorine, bromine and iodine; and R and R are independently selected from the group consisting of hydrogen and C 1 -C 6 alkyl; wherein C 1 C1-6 alkyl is optionally substituted with phenyl, wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C 1 C1-6 alkyl, C 1-4 alkoxy, amino, nitro and cyan. An international search report was published 2002.05.30