AGONISTS OF RECEPTORS ACTIVATED BY PEROXISOMAL PROLIFERATOR

摘要

The present invention relates to compounds represented by the following structural formula (I): and their pharmaceutically acceptable salts, solvates and hydrates, where n is 2, 3 or 4 and W is CH, CH (OH), C (O) or O; R1 is unsubstituted or substituted aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or t-butyl; R2 is H, alkyl, haloalkyl or phenyl; Y is unsubstituted or substituted thiophene-2,5-diyl or phenylene; R3 is alkyl or haloalkyl; R4 is a substituted or unsubstituted phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, quinolyl, pyridyl, or benzo [1,3] dioxol-5-yl group; and R5 is H, alkyl or aminoalkyl; which are used to modulate a peroxisomal proliferator-activated receptor, in particular for the treatment of diabetes mellitus. The international application was published along with an international search report.