the combination of fenofibrate and coenzyme q10 for the treatment of endothelial dysfunction

摘要

The present invention relates to a combination of a peroxisome proliferator activated receptor (PPAR) activator and a benzoquinone and their use in treating and/or preventing disorders characterized by endothelial dysfunction, such as cardiovascular disease, strokes and myocardial infarction. According to a preferred embodiment of the invention the benzoquinone or precursor thereof is a ubiquinone or precursor thereof, more preferably, coenzyme QSUB10 /SUBor a precursor thereof, and the PPAR activator is a fibrate or a thiazolidinedione, more preferably fenofibrate.