首页>
外国专利>
Antibiotic reuterin prepd. from Lactobacillus reuteri - has antifungal, antiparasitic, antiviral, anticancer and antibacterial activity
Antibiotic reuterin prepd. from Lactobacillus reuteri - has antifungal, antiparasitic, antiviral, anticancer and antibacterial activity
展开▼
机译:抗生素罗伊特林制备。来自路氏乳杆菌-具有抗真菌,抗寄生虫,抗病毒,抗癌和抗菌活性
展开▼
页面导航
摘要
著录项
相似文献
摘要
Antibiotic is produced by placing cells of Lactobacillus reuteri (LR) under conditions suitable for prodn. Pref. process is carried at in the presence of glycerol, and with a reduced oxygen tension. Also claimed is an antibiotic and its derivs., effective in inhibiting Gram-positive and Gram-negative bacteria and the eucaryotic organisms S. cerevisiae and Trypanosoma cruzi, contg., in wt.%, carbon, 48.65%; hydrogen, 8.11%; oxygen, 43.24%; having a mol. wt. of 148g per mole; being soluble in water; nonresistant to heat at pH9 and resistant to proteases and nucleases; and exhibiting characteristic elution with water of 0.01 M H2SO4 between 1,3-propanediol and glycerol on HPLC. The LR produces an antibiotic called reuterin. Reuterin is a broad-spectrum antimicrobial agent. J6 is also effective in preventing virus replication. LR may be added to animal food to optimise the conditions for reuterin prodn. in the gastrointestinal tract. Teuterin inhibits ribonucleotide reductase involved in DNA synthesis and can be used to inhibit the growth of bacteria, yeasts moulds, protoxoa, viruses and neoplastic and normal animal cells Reuterin is also an effective food preservative.
展开▼
机译:通过将罗伊氏乳杆菌(LR)细胞置于适合的条件下生产抗生素。首选该过程在甘油存在下并在降低的氧气张力下进行。还要求保护的是一种抗生素及其衍生物,可有效抑制革兰氏阳性和革兰氏阴性细菌以及真核生物啤酒酵母和克氏锥虫,按重量%计,碳含量为48.65%;氢8.11%;氧气43.24%;有痣。重量每摩尔148克;易溶于水;不耐pH9的高温,耐蛋白酶和核酸酶;并在HPLC上显示出在1,3-丙二醇和甘油之间用水0.01 M H2SO4洗脱的特征。 LR产生一种叫做路透林的抗生素。罗伊特林是一种广谱抗菌剂。 J6还可有效防止病毒复制。 LR可以添加到动物食品中,以优化路透素产品的条件。在胃肠道。 Teuterin抑制DNA合成中涉及的核糖核苷酸还原酶,可用于抑制细菌,酵母菌,原毒素,病毒以及赘生性和正常动物细胞的生长。Reuterin还是一种有效的食品防腐剂。
展开▼