PERMANENTLY IONIC DERIVATIVES OF STEROID HORMONES AND THEIR ANTAGONISTS

摘要

A pharmaceutical composition having bioaffecting activity selected from the group consisting of anti-inflammatory activity and anti-tumor activity which contains as an active ingredient a therapeutically effective quantity of a compound of the formula 3725 ט' בשבט התשס" ג - January 12, 2003 wherein Y- is any non-toxic pharmaceutically acceptable anion, drug is a steroid agonist or antagonist, mixed agonist-antagonist, or partial agonist and does not include a triphenyl ethyl or triphenyl ethylene moiety in which the ethyl or ethylene moieties are not additionally substituted; X is a direct bond or -O-, -NR6-, -S-, -SO-, -SO2-, or -PO3-; R1, R2 and R6 are independently H, alkyl of 1-10 carbon, aralkyl of 7-16 carbons or aryl; R3, R4, R5 are independently branched or unbranched, cyclic or noncyclic alkyl of 1-10 carbons, alkyl of up to 10 carbon atoms substituted by carboxy, hydroxy, alkoxy, halo, or nitro, branched or unbranched, cyclic or noncyclic arylalkyl of 7-16 carbons, aryl; n is 0-12; and a pharmaceutically acceptable solid diluent or solid carrier other than ethanol.