CONTROLLED RELEASE PHARMACEUTICAL DOSAGE FORMS FOR ORAL ADMINISTRATION CONTAINING NIFEDIPINE AS ACTIVE SUBSTANCE AND PROCESS FOR THEIR PREPARATION

摘要

Controlled release, oral pharmaceutical dosage forms containing nifedipine as active substance, characterized in that they comprise: an amorphous coprecipitate of nifedipine and polyvinylpyrrolidone; a hydrophile derivative of cellulose in an amount by weight ranging from 0.1 to 6 times with respect to the nifedipine; carboxypolymethylene and lactose in an amount by weight ranging from 0.1 to 5 times with respect to the nifedipine and a protective or retarding superficial coating, wherein the nifedipine release can be modulated from 8 to 24 hours. 548 כ" ז באייר התשס" ג - May 29, 2003