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PROCESS FOR THE PREPARATION OF POTASSIUM AND SODIUM SALTS OF N-PYRIDYL SULFONYL-N' PYRIMIDINYL UREAS, AND NOVEL POTASSIUM AND SODIUM SALTS OF 2-AMINOCARBOXYLAMINO-4, 6-DIMETHOXYPYRIMIDINE INTERMEDIATES THEREOF
PROCESS FOR THE PREPARATION OF POTASSIUM AND SODIUM SALTS OF N-PYRIDYL SULFONYL-N' PYRIMIDINYL UREAS, AND NOVEL POTASSIUM AND SODIUM SALTS OF 2-AMINOCARBOXYLAMINO-4, 6-DIMETHOXYPYRIMIDINE INTERMEDIATES THEREOF
N-Pyridylsulphonyl-N'-pyrimidinylurea sodium and potassium salts (I) are produced from a pyrimidinyl isocyanate (IV) either by reaction with a pyridyl sulphonamide salt (V) or by reaction with ammonia, conversion of the resulting new pyrimidinylurea (III) into a new pyrimidinylurea sodium or potassium salt (II) and reaction of this salt with a pyridylsulphonyl chloride (VI). Production of N-pyridylsulphonyl-N'-pyrimidinylurea sodium and potassium salts of formula (I) comprises: (A) reacting 4,6-dimethoxypyrimidine-2-isocyanate of formula (IV) with a pyridin-2-yl sulphonamide salt of formula (V) in an aprotic solvent; or (B) reacting (IV) with ammonia in an aprotic solvent, treating the resulting 2-aminocarbonylamino-4,6-dimethoxy-pyrimidine of formula (III) with sodium or potassium hydride, hydroxide, hydrogen carbonate or carbonate or a sodium or potassium alcoholate in an aprotic solvent and reacting the 2-aminocarbonylamino-4,6-dimethoxy-pyrimidine sodium or potassium salt of formula (II) obtained with a pyridin-2-yl sulphonyl chloride (VI). R1 = CO2CH3; CON(CH3)2; OCH2CF3; N(CH3)COCH3; N(CH3)SO2CH3; CF3; or SO2C2H5; R2 = H or CF3; M = Na or K. Independent claims are also included for 2-aminocarbonylamino-4,6-dimethoxy-pyrimidine (III) and its Na and K salts (II).
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