PROCESS FOR THE PREPARATION OS SALTS OF 5-PHENYLPENTANOYL-(S)-ALANYL-(S)-ARGINYL-(S)-ALANYL-{(S)-2-(r)-3-AMINO-2-OXOPYRROLIDIN-1-YLPROPIONYL}-(S)-ALANYL-(S)-ARGINYL-(S)-ALANYL-4-AMINOPHENYLACETAMIDE, INTERMEDIATES USED IN THE PROCESS AND PROCESS FOR THEIR PREPARATION

摘要

A process for the preparation of a salt of 5-phenylpentanoyl-(S)-arginyl-(S)-alanyl-{(S)-2-[(R)-3-amino-2-oxopyrrolidin-1-yl]propionyl}-(S)-alanyl-(S)-arginyl-(S)-alanyl-4-aminophenylacetamide (SEQ ID NO: 1) which comprises deprotection of a compound of the formula II or a salt thereof: wherein Pg and R1 are defined in the description. Also claimed are intermediates used in the process and the processes for the preparation of the intermediates.