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Nikotínamíð bíarýlafleiður, nytsamlegar sem hindrar PDE4 samsætuensíma
Nikotínamíð bíarýlafleiður, nytsamlegar sem hindrar PDE4 samsætuensíma
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机译:烟酰胺生物ryl衍生物,可用于抑制PDE4同工酶
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摘要
This application is directed to compounds useful as inhibitors at PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis and chronic obstructuive pulmonary disease, of the formula:where j is 0 or 1 provided that when j is 0, n must be 2; k is 0 or 1; m is 0, 1, or 2; n is 1 or 2; W1 is -O-; or -S(=O)t-, where t is 0, 1, or 2; Y is -C(R1a); Q1 is phenyl or substituted phenyl; Q2 is biphenyl or substituted biphenyl; and the remaining variables are defined as set forth in the specification. This application is also directed to pharmaceutical compositions comprising those compounds and to methods of treating diseases regulated by the activation and degranulation of eosinophils, in particular asthma, chronic bronchitis and chronic obstructive pulmonary disease.
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