(1R, 9S, 12S, 13R, 14S, 17R, 18E, 21S, 23S, 24R, 25S, 27R) -12 - ((1E) -2 - ((1R, 3R, 4S) -4-chloro-3- méthoxycyclohenyl) -17-ethyl-1,14-dihydroxy-23.25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo (22.3.1.04,9) octacos-18-ene-2 , 3,10,16-tetraone or 4 '-epichloro-4' deoxyascomycin; in any form including, where appropriate, its salts and esters

摘要

The invention concerns the compounds of formula I CHEM wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with an acid having a non-nucleophilic anion, treatment with dimethylsulfoxide and acetic anhydride, acylation, treatment with an oxalyl derivative and ammonia, methylation, oxidation, deprotection and protection. They possess interesting pharmacological activity as antiinflammatory, immunosuppressant, antiproliferative and chemotherapeutic drug resistance reversing agents.