PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TISSUE DAMAGE OWING TO AN ARTERIAL IRRIGATION DEFECT.

摘要

The invention relates to human medicine and, more specifically, to a pharmaceutical combination of the Epidermal Growth Factor (EGF) and a mimetic peptide of the Growth Hormone Release Factor (GHRP), which is useful in the prevention and/or repair of tissue damage caused by insufficient blood supply to a particular organ owing to different pathological conditions. Said combination can be used in one single pharmaceutical composition or applied separately to an individual as part of a unique treatment that encourages cellular vitality in organs when the latter are subject to a partial or total loss in the supply of oxygen-rich blood for a period of time. The combination also diminishes the formation of toxic species and metabolites in said organs, which is particularly useful for tissues that are subjected to prolonged periods of ischemia. Moreover, said pharmaceutical combination can be applied, for prophylactic purposes, to patients with conditions that could cause a dysfunction in or multiple damage to the organs, for example owing to burns, polytraumatisms, respiratory distress syndrome, hypoxemia among newborns, hypovolemic shock, necrotising enterocolitis. The inventive combination can also be applied to patients undergoing important surgical operations.