4 AMINO 5 CYANO 2 ANILINO PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CELL CYCLE KINASES.

摘要

Compounds of formula (I) wherein: R1 is halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, C1 6alkyl, C2 6alkenyl or C2 6alkynyl; p is 0 4; wherein the values of R1 may be the same or different; R2 is sulphamoyl or a group B E ; wherein B is optionally substituted as defined within and is selected from C1 6alkyl, C2 6alkenyl, C2 6alkynyl, C3 8cycloalkyl, C1 6alkyl, phenyl, a heterocyclic group, phenylC1 6alkyl or (heterocyclic group)C1 6alkyl; E is C(O) , N(Ra)C(O) , C(O)N(Ra) , S(O)r , SO2N(Ra) or N(Ra)SO2 ; wherein Ra is hydrogen or C1 6alkyl optionally substituted as defined within and r is 1 2; q is 0 2; wherein the values of R2 may be the same or different; and wherein p plus; q = 1 5; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof are described. Processes for their manufacture and their use as inhibitors of cell cycle kinases, particularly CDK2, CDK4 and or CDK6 are also described.