Camptothecin tetracyclic derivatives useful for inhibiting topoisomerase I and/or II pyridine intermediates thereof

摘要

Tetracyclic analogues of camptothecin of formula (I), their preparation processes, their use as medicaments and the pharmaceutical compositions containing them, where: R1, R2, R3, R4, R5 and R10 are as described in the specification. These Tetracyclic analogues of camptothecin, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity inhibiting topoisomerase I and/or topoisomerase II.