Liquid polymeric compositions for controlled release of bioactive substances using a polymer to active agent ratio of less than 1:1

摘要

A liquid polymeric composition for controlled release of hydrophobic bioactive substances comprising: a) 1 to 30% w/v of a hydrophobic active substance; b) 1 to 20% w/v of a poly(lactide-co-glycolide) copolymer; wherein the weight ratio of the poly(lactide-co-glycoide) copolymer to the hydrophobic bioactive substance id 1:1 or less; and c) a mixture of hydrophilic and lipophilic solvents is from about 80:20 to about 5:95; and the use of such a composition in the manufacture of a medicament for the controlled release of a hydrophobic bioactive substance in an animal.