Process and conjugated forms of PEGylated interferon- beta with polyethylene glycol (PEG) wherein the thiol reactive polyol agent is mono-methoxylated

摘要

A polyol-interferon-â conjugate having a polyol moiety (which is a polyethylene glycol (PEG) moiety) covalently bound to Cys17 of human interferon- â. The above-described compound may be used to treat infections, tumors and autoimmune diseases. A method for stepwise attachment of PEG moieties in series to a polypeptide.