DNA immunization to generate protective antibodies to a fragment of a major outer membrane protein (MOMP) of a strain of Chlamydia that encompasses epitopic sequences

摘要

A vector in an immunogenic composition comprising a nucleic acid such as DNA for immunization to generate a protective immune response in a mammalian host, including humans, to a major outer membrane protein (MOMP) of a strain of Chlamydia is described. Preferably the immunogenic composition contains a nucleotide sequence encoding a fragment that generates antibodies that specifically react with the MOMP and a promoter sequence operatively coupled to the first nucleotide sequence for expression of the MOMP fragment in the host. The non-replicating vector may be formulated with a pharmaceutically-acceptable carrier for in vivo administration to the host.