Antiviral macrocyclic compounds containing a cyclic amine moiety

摘要

A macrocyclic compound or the acid addition salts and metal complexes thereof has the formula (V): V'-CR1R2-Ar2 or of formula (1a) V"-CR1R2-Ar1-CR3R4-N(R5)-(CR6R7)x-R8 wherein: V' is a cyclic polyamine moiety having a total of 9 to 24 members and from 3 to 6 optionally substituted amine nitrogens spaced by two or more optionally substituted carbon atoms from each together and which may optionally comprise a fused aromatic or heteroaromatic ring; V" is a cyclic polyamine moiety having a total of 9 to 24 members and 2 optionally substituted amine nitrogens spaced by two or more optionally substituted carbon atoms from each together and which may optionally comprise a fused aromatic or heteroaromatic ring;R1 to R7 are independently hydrogen, alkyl or cycloalkyl; Ar1 is an optionally substituted aromatic or heterocyclic group; Ar2 is an optionally substituted aromatic or heterocyclic group or is 4- phenylpiperazinyl or purin-1-ylmethyl; R8 is a heterocyclic group, an optionally substituted aromatic or heteroaromatic group or is mercaptan and x is 1 or 2. The compounds are useful in treating conditions mediated by the CXCR4 or CCR5 receptors.