Combinations of a vascular damaging agent and a inhibitor of the formation or action of nitric oxide for the treatment of diseases involving angiogenesis

摘要

Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vascular damaging agent, other than a cytokine releasing anticancer agent, and an inhibitor of the formation or action of nitric oxide in mammalian systems. There are also provided the use of said combinations in medicaments and kits of said compounds and treatment employing said materials. Particularly preferred vascular damaging agents include tubulin-binding agents and antibodies targeted to vasculature, and more preferably include N-acetylcolchinol and N-acetylcolchinol-O- phosphate. Preferred nitric oxide inhibitors include derivatives of arginine, ornithine, lysine, citrulline, S- alkylthioureas or aminoguanidine. Such compositions are useful in the treatment of diseases involving active angiogenesis, such as cancer, especially solid tumors, psoriasis, diabetic retinopathy, macular degeneration, artherosclerosis and rheumatoid arthritis.