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Mice that are homozygously deficient in CRFR2 and uses thereof in drug screening
Mice that are homozygously deficient in CRFR2 and uses thereof in drug screening
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机译:CRFR2纯合缺陷的小鼠及其在药物筛选中的用途
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摘要
Disclosed are transgenic mice deficient in corticotropin releasing factor receptor 2 (CRFR2). CRFR2 mutant mice are hypersensitive to stress, and display increased anxiety-like behavior. The mice have homozygous defective CRFR2 genes, and exhibit a phenotype of increased anxiety behavior, a hypersensitive hypothalamic-pituitary- adrenal (HPA) axis response to stress and a muted cardiovascular response to urocortin administration. Such knockout mice are useful for screening compounds for anxiety modulating activity, blood pressure control and effect on the response of the hypothalamic-pituitary- adrenal (HPA) axis to stress.
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