Process for the preparation of rofecoxib

摘要

Anti-inflammatory Compound 4 - [4 '- (methylsulfonyl) phenyl] - 3 - phenyl - 2 (5H) - furanona (rofecoxib) is prepared from a New intermadiario Compound, 4 - (4' - iodo - phenyl] - 3 - phenyl - 2 (5H) - furanona,By the same metilfunacion using a Metallic Salt of metilsulfinato aprotico in a Solvent, preferably in the presence of copper (i) as a Catalyst.