Pyrethroid-5-ona (4,3-a) derivatives of pyrethroids, compounds containing pyrethroids, preparation methods and uses

摘要

1. It refers to the ring with X as h, oh, halogeno, amino, nitro, mercato, Ciano, carbocilo, Aquilo, alcoxi, aquito, aquiltio, aquilsulfonilo, n3r4, [n (a)] ncoq1q2q3, 3-10 members may contain other heterogeneity; n is 0-1, when it is 1, a, qqq2q3; This is OXI-O.Oil, tar, 1, mix mix mix mix coagulation, 1, or with 1, 1, 1, 1, 1-1-1-1-y3, ch3-ch2ch = ch-ary1y2y3; s is 1-4; AR is arilo; Y1, Y2, Y3 is h, hydroxy, mercato, amino, nitro, cor6, coor6, conr6r7, etc.; R3 and R4 are h, Aquilo, cor5, (CH2) x-cycloquilo; R1 and R2 are tar, aralquilo, cycloquilo, cyclo clalquilo, fenilalquilo. 1-（Azepin-1-il）-4-Bencil-4h-triazolo-[4，3-a]pirido[2，3-d]pirimidin-5-ona；1 - (azepin-1-il) - 4-cinamil-4h-triazolo - [4, 3-A] pirido [2, 3-d] pirimidin-5-ona; 4-bencil-1 - (pirrolidin-1-il) - 4h-triazolo - [4, 3-A] pirido [2, 3-d] pirimidin-5-ona; and so on. It also refers to a preparation procedure and intermediate compounds. These compounds inhibit the enzyme PDE4 and / or release TNF or can be used to treat cancer, acquired immunodeficiency syndrome, fibrosis, over formation of skin scars.