BIOLOGICALLY ACTIVE SUBSTANCE, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HERPETIC INFECTIONS AND UTILIZATION OF SAID BIOLOGICALLY ACTIVE SUBSTANCE

摘要

The invention relates to a biologically active substance, to a process for preparing said substance, to a pharmaceutical composition for treating herpetic infections and to the utilization of said biologically active substance. According to the invention, the biologically active substance comprises 4.5 mg Glu/ 100 mg, 1.47 mg Tre/100 mg, 1.27 mg Cer/100 mg, 1.53 mg Pro/100 mg, 0.25 mg Cis/ 100 mg, 1.39 mg Gly/ 100 mg, 1.71 mg Ala/ 100 mg, 1.24 mg Val/ 100 mg, 0.10 mg Met/ 100 mg, 1. 26 mg Izo/ 100 mg, 1.77 mg :Ley/ 100 mg, 1.11 mg Pir/ 100 mg, 3.17 mg Fen/ 100 mg, 2. 99 mg Asp/ 100 mg, 1.99 mg Arg/ 100 mg, 0.63 mg His/ 100 mg, 0.12 mg Tri / 100 mg. The process for preparing the biologically active substance consists in the steps of: a) growing on a large scale the Galeria mellonella insect in artificial culturing environments, under laboratory conditions; b) selecting one kilo of larvae in a last stadium of development, when insects do not feed themselves and their intestine becomes sterile; c) disinfecting the larvae surface with a detergent in a concentration of 15 ... 20 ml to 2 l of warm water at a temperature ranging from 30 to 35 degree C, washing the larvae three-four times, rinsing the larvae two-three times with double distilled water, subjecting the surface of the bodies of the larvae to UV radiation from a distance of 1 to 1.5 m for 2 to 2.5 min for a total disinfection; d) grinding the sterile larvae for 10 to 15 min till an homogeneous mass of grey light colour is obtained; e) filtering the suspension by means of a very fine mesh with orifices ranging from 200-300 micro in order to remove the larvae tissues remaining from the grinding; f) centrifuging the suspension at a speed of 5, 000 -5, 500 rpm, for 30 -35 min until there do not settle all the proteins any longer; g) lyophilizing or atomizing the suspension at a temperature ranging from -150 ... 160 degree C or at a temperature ranging from 170 ... 180 degree C at the input and 85 ...90 degree C at the output; h) collecting 250 g dry powder and preserving the same at a temperature ranging from 15 to 20 degree C.