SUSPENSION OF FIBRINOGEN, THROMBIN, AND ALCOHOL, METHOD FOR ITS PREPARATION, METHOD FOR COATING CARRIER, METHOD FOR DRYING CARRIER COATED WITH SUSPENSION OF FIBRINOGEN, THROMBIN, AND ALCOHOL, COLLAGEN SPONGE COATED WITH SUSPENSION OF FIBRINOGEN, THROMBIN, AND ALCOHOL, USE OF COATED COLLAGEN SPONGE FOR TISSUE GLUING, TISSUE SEALING AND HAEMOSTASIS

摘要

A suspension of fibrinogen, thrombin, alcohol and optionally aprotinin is obtained by mixing fibrinogen in alcohol with thrombin in alcohol. The suspension contains fibrinogen and thrombin particles with a Folk Ward mean diameter of 25-100 m. The thrombin may be human, bovine or recombinant. The fibrinogen may be human or recombinant. A method for coating a carrier, such as a collagen sponge, with the suspension, and a method for drying the coating is disclosed. The coated collagen carrier may be used as a ready-to-use absorbable composition for tissue gluing, tissue sealing and haemostasis wherein the carrier is coaled with solidly fixed components of fibrin glue, i.e. fibrinogen and thrombin.