INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF DUOCARMYCIN SA AND ITS DERIVATIVES AND A METHOD FOR THE PRODUCTION OF THE INTERIM PRODUCTS

摘要

Indole derivatives shown by the formulae (1), (2a) and (2b) CHEM (wherein R1 is a protecting group for amino group; R2 is a protecting group for hydroxyl group; R3 is a protecting group for hydroxyl group; R4 is a C1-C6 linear or branched lower alkyl group, or benzyl group), and pyrroloindole derivatives shown by formula (3) CHEM (wherein R1 is a protecting group for amino group; R2 is a protecting group for hydroxyl group; R3 is a protecting group for hydroxyl group; R4 is a C1-C6 linear or branched lower alkyl group, or benzyl group), both of which are intermediates for duocarmycin SA, which is expected to be used as an anticancer agent, and derivatives thereof; and a method for producing the same.