Dissociation racementos of primary and secondary amines, substituted by hteroatomos acylated by enzymatically catalysed.

摘要

SE discloses a process for the preparation of primary and secondary amines substituted hetero optically active from the corresponding racemate, which comprises a) an amine RACEMIC REPLACED WITH HETEREOATOMOS acylated SELECTIVELY relative to the enantiomer with an ester whose components ACIDS CARRY a fluorine, nitrogen, phosphorus, oxygen or sulfur atom adjacent to the carbonyl carbon in the presence of a hydrolase, B) mixing amine substituted with hetero atoms optically active amine-substituted hetero atoms acylated and optically active SPREADING WITH WHAT YOU GET A enantiomer of amine substituted with hetero atoms (C) MAY EVENTUALLY BE OBTAINED FROM acylated hetero atoms substituted amine the other enantiomer of the amine-substituted hetero atoms by removal of the amide.