GUIDELINES OF AQUIL-CARBOXILIC ACID REPLACED WITH PHENYLL AND CARRIER OF PPERFLUORALQUILO GROUPS, PROCEDURE FOR THEIR PREPARATION, ITS USE AS A MEDICINAL OR DIAGNOSTIC AGENT AS WELL AS MEDICINES CONTAINING THEM.

摘要

GUANIDINE ACID CARBOXILIC ACID SUBSTITUTED RENTAL COMPOUNDS ARE DESCRIBED THAT CARRIES GROUPS PERFLUOR RENT OF FORMULA I WITH RA) YR (B) EQUAL AH, HAL, CN, OR (6), RENT, OR - PERFLUOR RENT, NR (7) R ( 8); R (6) EQUAL TO HYDROGEN, (CYCLE) ALQ (EN) IL, PERFLUOR ALQUIL, FENIL, BENCIL; R (7) AND R (8) ARE DEFINED AS R (6); X EQUAL TO 1 - 3; R (1) EQUAL TO H, RENT, - O0 - 1 (CH2) 0 - 1 PERFLUOR RENT; R (2), R (3), R (4) YR (5) ARE DEFINED AS R (1), HOWEVER UNDER THE CONDITION, THAT R (1), R (2), R (3), R (4) YR (5) ARE NOT EQUAL TO HYDROGEN, AND THAT R (1), R (2), R (3), R (4) YR (5) CAN BE THEN ONLY RENT, WHEN AT LEAST ONE OF THE R (A) OR (B) SUBSTITUTES CONTAIN A GROUP OR (CH2) ACBF2B + 1; AS WELL AS YOUR TOLERABLE SALTS PHARMACEUTICALLY. THE COMPOUNDS I ARE OBTAINED BY TRANSFORMATION OF A COMPOUND II WITH GUANIDINE, WHERE IT IS A LIGHT NUCLEOPHYL REPLACABLE GROUP. THE COMPOUNDS I ARE INHIBITORS OF CELLULAR PROTON SODIUM ANTIPORTERS (NA + H + -EXCHANGER). THEY ARE APPROPRIATE PREVENTIVE PARATERAPY, IN ORDER TO PREVENT THE GENESIS OF HIGH PRESSURE ARTERIAL, FOR EXAMPLE OF ESSENTIAL HYPERTONIES.