AZETIDINONE ENANTIOSELECTIVE SYNTHESIS BASED ON 3-HYDROXY-GAMMA-LACTONS.

摘要

THE INVENTION REFERS TO A PROCESS FOR THE PRODUCTION OF A FORMULA COMPOUND (I) IN WHICH R 1, R 2 AND R SUB, 3 REPRESENT THE DEFINITION IN THE SPECIFICATION, WHICH IS TO REACT A LACTONE WITH A IMINA TO OBTAIN A FORMULA QUIRAL DIOL (IV), OXIDATE THE DIOL, CONDENSE THE RESULTING ALDEHYDE WITH AN ENOLETER, HYDROGEN THE PRODUCT AND QUIRALLY REDUCE THE RESULTING KETONE BY CATALYZING.