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Nerve regeneration tube for use in medicine to promote regrowth of damaged nerves has smooth, compact exterior surface and fibrous inner surface, and is made from mixture of type I and III collagens
Nerve regeneration tube for use in medicine to promote regrowth of damaged nerves has smooth, compact exterior surface and fibrous inner surface, and is made from mixture of type I and III collagens
A nerve regeneration tube comprising a resorbable side wall of a collagenic matter which has a smooth and compact exterior surface, which inhibits adherence of cells to it and acts as a barrier to hinder passage of cell through it, and a fibrous interior wall. Preferred Features: The sidewall is formed of a mixture of type I and type III collagens. It contains most preferably 1-5 % type I and 95-99% type III. It contains a filling consisting of type I or type IV collagen or a 1:1 by weight mixture of the two of which the fibers are oriented longitudinally with respect to the tube. The filling also includes a nerve growth stimulant (laminine) or nerve growth factor or a mixture of the two. The tube wall is derived from collagen containing membrane, preferably peritoneum. The tube is constructed from a sheet of material with a smooth side and a fibrous side, which is formed into the tube with the fibrous side innermost by sutures or an adhesive.. The tube is then filled with the filling. It is disclosed that a suitable material is Bio-Gide (TM), the formation of which is described in US Patent No. 5837278
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