HEVEIN-BINDING MONOCLONAL ANTIBODIES

摘要

This invention relates to antibody engineering technology. More particularly,the present invention relates to human IgE antibodies and derivatives thereof,which bind allergenic hevein with high affinity and specificity. The presentinvention also relates to processes for making and engineering such hevein-binding monoclonal antibodies and to methods for using these antibodies andderivatives thereof in the field of immunodiagnostics, enabling qualitativeand quantitative determination of allergenic hevein in biological and rawmaterial samples, as well as in immunotherapy, enabling blocking of allergenichevein in allergic patients.