SELECTIVE ANTHRANILAMIDE PYRIDINAMIDES AS VEGFR-2 AND VEGFR-3 INHIBITORS

摘要

The invention relates to selective anthranilamide pyridine amides asinhibitors of VEGFR-2 and VEGFR-3 and to their production and use asmedicaments for treating diseases that are caused by persistent angiogenesis.The inventive compounds can be used for example in cases of psoriasis,Kaposi's sarcoma, restenosis, such as e.g. stent-induced restenosis,endometriosis, Crohn's disease, Hodgkin's disease, leukaemia, arthritis, suchas rheumatoid arthritis, haemangioma, angiofibromatosis, in eye diseases suchas diabetic retinopathy, neovascular glaucoma, in kidney diseases such asglomerulonephritis, diabetic nephropathy, malign nephrosclerosis, thrombicmicro-angiopathic syndrome, transplant rejection and glomerulopathy, infibrotic diseases such as hepatic cirrhosis, mesangial-cell proliferativediseases, arteriosclerosis, damage to the nerve tissue and inhibition of there-occlusion of vessels after balloon catheter treatment, in vesselprosthetics or after the use of mechanical devices for keeping vessels open,e.g. stents, as immunosuppressants, to support wound healing without scars andin cases of age spots and contact dermatitis. The inventive compounds can alsobe used as inhibitors of VEGFR-3 in lymphangiogenesis for hyperplastic anddysplastic changes in the lymphatic system.