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NOVEL PIPERIDIN-2,6-DIONE BISULPHATE SALTS AND THEIR USE FORTHE TREATMENT OF STRESS-RELATED AFFECTIVE DISORDERS
NOVEL PIPERIDIN-2,6-DIONE BISULPHATE SALTS AND THEIR USE FORTHE TREATMENT OF STRESS-RELATED AFFECTIVE DISORDERS
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机译:新型哌替啶2,6-二酮双硫酸盐及其在治疗与应激有关的情感障碍中的用途
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摘要
Novel bisulphate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4- dimethylpiperidin-2,6-diones and pharmacologically acceptable solvates there of are devoid of the weight loss and hepatocyte changes in the rat which limite d to marginally effective levels the permitted clinical doses of the corresponding hydrochlorides in the treatment or prophylaxis of stress-relat ed affective disorders such as anxiety, depression, migraine and sleep apnoea. The preferred bisulphate salts are 3(3,5-dimethoxyphenyl)-3-(3- dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione bisulphate and, especially, 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4- dimethylpiperidine-2,6-dione bisulphate.
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