Derivatives of the (3s, 4ar, 6s, 8ar) 6-phenylamino-1, 2, 3, 4, 4a, 5, 6, 7, 8, 8a-decahydro isoquinoline-3-carboxylic acid as excitatory amino acid receptor antagonists for the treatment of neurological disorders and neurodegenerative diseases

摘要

The present invention provides novel compounds of Formula (I), or the pharmaceutically acceptable salts or prodrugs thereof, and methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine wherein R1 is H, CO2H, tetrazole, OH, or (C1-C4)alkyltetrazole; R2 is H, (C1-C6)alkyl, aryl, halo, CO2H, (C1-C6)alkyl-heterocycle, (C1-C6)alkyl-(substituted)heterocycle, (C1-C4)alkyl-N-SO2-aryl, NO2, NH2, CF3, or (C1-C6)alkoxy carbonyl, NSO2aryl; W, X, and Y each independently represent H, (C1,C6)alkyl, CO2H, halo, OH; heterocycle, substituted heterocycle, CF3, (CH2)nCO2H, (C1-C6)alkoxy, or (C1-C6)alkoxy carbonyl; or optionally, X and R2 together, along with the carbon atoms to which they are attached, form a fused-benzo group, or optionally, W and R1 together, along with the carbon atoms to which they are attached, form a fused-benzo group or a fused-triazole group; n is 0, 1, or 2, or a pharmaceutically acceptable salt or prodrug thereof.