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Molecular linkers suitable for crystallization and structural analysis of molecules of interest, method of using same, and methods of purifying g protein-coupled receptors
Molecular linkers suitable for crystallization and structural analysis of molecules of interest, method of using same, and methods of purifying g protein-coupled receptors
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机译:适用于目标分子的结晶和结构分析的分子接头,其使用方法以及g蛋白偶联受体的纯化方法
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摘要
A method of crystallizing a molecule-of-interest is disclosed. The method comprises (a) contacting molecules of the molecule-of-interest with at least one type of heterologous molecular linker being capable of interlinking at least two molecules of said molecule-of-interest to thereby form a crystallizable molecular complex of defined geometry; and (b) subjecting said crystallizable molecular complex to crystallization-inducing conditions, thereby generating the crystal containing said molecule-of-interest.
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