NOVEL USE OF THE EXTRACT OF PROCESSED PANAX GENUS PLANT AND SAPONIN COMPOUND ISOLATED THEREFROM

摘要

The present invention relates to novel use of the extract of processed Panax genus having anti-Helicobacter pylori activity. More particularly, the present invention relates to a processed Panax genus extract with enhanced pharmacological effects due to subsequent treatment i.e., acid-treatment or heat-treatment of a Panax genus plants and bio-converting treatment such as lactic acid bacterial fermenting and intestinal bacterial fermenting process so as to make a ratio of ginsenoside (Rk2 + Rh3 + protopanaxadiol + 20-dehydroprotopanaxadiol) to (Rg3 + Rg5 + Rk1) of above 0.1. The processed extract of Panax genus plant in the present invention has inhibitory effect for Helicobacter pylori bacteria and H+/K+-ATPase enzyme and, therefore, it is useful in the prevention or treatment of gastrointestinal diseases caused by abnormal proliferation of Helicobacter pylori such as gastritis, gastric ulcer, duodenal ulcer and gastric cancer.