The present invention relates to novel therapeutic use of byakangelicin. More particularly, the present invention relates to method for treating disease or disorder associated with inflammation comprising administering the byakangelicin into a patient, a method for inhibiting the production of TNF-alpha comprising administering the byakangelicin into a patient, a pharmaceutical composition comprising the byakangelicin and use thereof. The byakangelicin according to the present invention can be used effectively in treatment or prevention of disease or disorder with inflammation, especially septic shock, and inhibition of the production of TNF-alpha.
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