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POINT MUTANT MICE WITH HYPERSENSITIVE ALPHA 4 NICOTINIC RECEPTORS: DOPAMINERGIC PATHOLOGY AND INCREASED ANXIETY
POINT MUTANT MICE WITH HYPERSENSITIVE ALPHA 4 NICOTINIC RECEPTORS: DOPAMINERGIC PATHOLOGY AND INCREASED ANXIETY
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机译:高敏α4烟碱受体的点突变小鼠:多巴能病理学和焦虑增加
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摘要
The present invention relates to transgenic animals expressing a hypersensitive nicotinic acetylcholine receptor. Transgenic animals have point mutations in the nucleic acid sequence encoding the alpha 4 subunit of the receptor that result in increased sensitivity to nicotine. Such transgenic animals are model systems for nicotine addiction and certain types of epilepsy.
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