COMPOSITE HAPLOTYPE COUNTS FOR MULTIPLE LOCI AND ALLELES AND ASSOCIATION TESTS WITH CONTINUOUS OR DISCRETE PHENOTYPES

摘要

Haplotype frequencies for a plurality of individuals are associated with a continuous trait. Each individual includes a pair of chromosomes having a plurality of markers thereon. Each marker has a pair of alleles for an individual. A haplotype includes a combination of alleles for a set of markers on a predetermined chromosome. A subset of markers from the set of markers that may correlate with the continuous trait, is selected. A value of the continuous trait, and a pair of alleles for each of the markers in the subset of markers, is obtained for each individual. For each individual, probabilities of haplotypes that are compatible with the alleles in the subset of markers is determined. Finally, a regression is performed on the probabilities of haplotypes that are compatible with the alleles in the subset of markers, for all the individuals, to determine correlation between the continuous trait and the haplotypes.