RECOMBINANT ADENOVIRUS VECTOR PRODUCING TUMOR-SUPPRESSOR E2 PROTEIN AND THE USE THEREOF

摘要

The present invention relates to a recombinant adenovirus vector, in which a tumor-suppressor E2 gene is inserted, and the use thereof. The E2 protein has an inhibitory effect on oncogene expression, and an effect of inducing cellular senescence. As a result, the E2 gene-inserted recombinant adenovirus vector can be used in gene therapy, capable of effectively treating patients in the terminal stage of cancer. Cell line, in which cellular senescence is induced by infection with the recombinant adenovirus vector, can be used in selecting substances inhibiting cellular senescence.