Oral drug composition containing a verapamil derivative as a drug-absorption promotor

摘要

The bioavailability of a drug which is not readily absorbed in the digestive tract can be greatly enhanced by administering an oral composition comprising a drug and a compound of formula (I): wherein,X is CN, COOH, COOR10(wherein R10 is C1-2 alkyl), SO2Ph or SPh;k, l, m and n are each independently an integer of 0 to 4;R1 is H or C1-3 alkyl; andR2, R3, R4, R5, R6, R7, R8 and R9 are each independently H, OH or C1-3 alkoxy.