METHODS FOR IDENTIFYING THERAPEUTIC AGENTS FOR TREATING DISEASES INVOLVING WNT POLYPEPTIDES AND WNT RECEPTORS

摘要

Mutations in Wnt receptor genes, such as FZD4, associated with hereditary human visual disorders, such as familial exudative vitreoretinopathy ('FEVR'), are disclosed along with methods of use of Wnt and/or Wnt receptor genes and proteins, including in assays for therapeutic agents useful in treating such diseases and/or ameliorating their effects as well as methods of diagnosing diseases and disorders caused by mutations in these genes.