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METHODS FOR IDENTIFICATION OF ACTIVATORS OF G PROTEIN-COULPLED RECEPTORS AND NUCLEIC ACIDS ENCODING THOSE RECEPTORS
METHODS FOR IDENTIFICATION OF ACTIVATORS OF G PROTEIN-COULPLED RECEPTORS AND NUCLEIC ACIDS ENCODING THOSE RECEPTORS
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机译:识别G蛋白偶联受体和编码这些受体的核酸的活化剂的方法
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摘要
The present invention provides methods for identifying activators of G protein-coupled receptors (GPCRs) and for identifying nucleic acids encoding the receptor(s) for each identified activator. The present invention is directed at the generation of GPCR-encoding nucleic acid pools for expression in oocytes, the generation of compound pools, and the multiplex screening of both the compound and nucleic acid pools. Through successive subdivision of both the compound and nucleic pools into subpools, both activators and GPCR nucleic acids are identified from complex compound and receptor repertoires.
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