USE OF RECIPIENT ENDOTHELIAL CELLS FOR ENHANCED VASCULARIZATION OF TISSUE AND TISSUE-ENGINEERED CONSTRUCT TRANSPLANTS

摘要

The success of tissue transplantation, when immunological conflict is minimized, depends on the vascularization process. This process is very complex and requires time. During this time, transplanted tissue often has difficulty obtaining oxygen and nutrients. These factors have a profound influence on the survival of the transplanted tissue, especially if the tissue has poor angiogenic properties. For new vessel formation, endothelial cells from existing recipient microvessels must proliferate and migrate through the extracellular matrix into the transplanted tissue. However, if transplanted tissue is mixed with recipient endothelial cells or co-administered, vascularization and acceptance of auto-, allo-, and heterotransplants is enhanced. In addition, recipient endothelial cells can be used to enhance vascularization of three-dimensional tissue-engineered constructs.