A METHOD FOR IDENTIFYING EFFECTOR MOLECULES FOR GENE NETWORK INTEGRATION

摘要

The present invention relates generally to the field of bioinformatics and its applications to functional genomics and advanced genetic engineering. More particularly, the present invention contemplates a method for identifying effector molecules capable of modulating gene network integration and which facilitate genetic multi-tasking and the regulation of complex suites of programmed responses within, on and between eukaryotic cells. The present invention permits, therefore, the identification of a new generation of proteome and nucleome modulators useful in a range of therapeutic and trait-modifying protocols. The ability to manipulate genetic networks within a cell and within whole organisms also provides a sophisticated genetic engineering approach of introducing new traits and to influencing the genetic architecture and, hence, to enable cell and organismal programming or re-programming. The identification of effector molecules and their target or receiver sites, further enables the development of diagnostic protocols for a range of conditions or physiological or genetic states of an organism useful, for example, in modulating stem cell differentiation, quantitative traits, aging or the development of pathological conditions.