首页> 外国专利> INDANE DIMER COMPOUNDS WITH SMOOTH MUSCLE RELAXING AND/OR MAST CELL STABILISING AND/OR ANTIINFLAMMATORY ACTIVITY

INDANE DIMER COMPOUNDS WITH SMOOTH MUSCLE RELAXING AND/OR MAST CELL STABILISING AND/OR ANTIINFLAMMATORY ACTIVITY

机译:具有平滑肌松弛和/或肥大细胞稳定和/或抗炎活性的茚满二聚体化合物

摘要

Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 to R13, in formula (8) R1 and R3 and R13 are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing heretro atoms containing one or more of N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may saturated or unsaturated, substituted alkyl or cycloalkyl groups which may be saturated or unsaturated. X is a bond, O, or NR (wherein R is acyl, alkyl or sulphonate groups), S, SO or SO2, when X is a bond any of R8 and R13; R8 and R12; R8 and R9 may together represent a double bond, in formula (7) any one or more of R2, 1R2 R3, 1R3; R9, 1R9; R10, 1R10; R11, 1R11; R12, 1R12 may together represent oxo, and in formula (8) any one or more of R1, 1R1, R3, 1R3; R9, 1R9; R10, 1R10; R11, 1R11; R12; 1R12 may together represent oxo.
机译:通式(7)和(8)的茚满化合物及其药物用途,特别是用于实现所述的平滑肌松弛活性和/或肥大细胞稳定活性和/或抗炎活性,其中在式(7)中,R2至R13在式(8)中,R 1和R 3和R 13选自以下相同或不同的一个或多个:H,卤素,羟基,烷氧基,芳氧基,乙酰氧基,羧基,烷基羰基,氢羰基,氨基,酰胺基,烷基氨基,羟基氨基,氧化胺基团,偶氮基团,氰基,肼基基团,酰肼基团,基团,酰亚胺基团,亚氨基醚基团,脲基,肟,硝基,硝酸盐,亚硝酸盐,亚硝基基团,腈基,杂环基团,含有含有一个或多个的本文N,O或S,芳烷基,单和聚苯甲酰基芳基,取代的芳基,硫醇,硫脲基,苯硫醇基,磺酸基,亚砜基,砜基,含1至10个碳原子的烷基或含3至10个碳原子的环烷基8可为饱和或不饱和的碳原子,可为饱和或不饱和的取代的烷基或环烷基。当X是R 8和R 13中任何一个的键时,X是一个键,O或NR(其中R是酰基,烷基或磺酸根基团),S,SO或SO 2; R8和R12;在式(7)中,R 8和R 9可以一起表示双键,R 2,1R 2,R 3,1R 3中的任一个或多个; R9、1R9; R10、1R10; R11、1R11; R12、1R12可以一起表示氧代,在式(8)中,R1、1R1,R3、1R3中的任一个或多个; R9、1R9; R10、1R10; R11、1R11; R12; 1R12可以一起代表氧代。

著录项

  • 公开/公告号EP0874800B1

    专利类型

  • 公开/公告日2003-08-06

    原文格式PDF

  • 申请/专利权人 VENANTIUS LIMITED;

    申请/专利号EP19960942551

  • 申请日1996-12-06

  • 分类号C07C225/20;C07C215/44;C07C233/32;C07C311/20;C07C43/188;A61K31/13;A61K31/16;A61K31/18;A61K31/075;

  • 国家 EP

  • 入库时间 2022-08-21 23:53:47

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