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Method for making mineralized collagen fibrils from recombinant collagen and their use as bone replacement material
Method for making mineralized collagen fibrils from recombinant collagen and their use as bone replacement material
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机译:由重组胶原蛋白制备矿化胶原蛋白原纤维的方法及其作为骨替代材料的用途
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摘要
Mineralised collagen fibrils are produced by a one step fibril formation and mineralisation. Also, a collagen/calcium phosphate composite is manufactured by embedding the resulting fibrils in a calcium phosphate cement. Production of mineralised collagen fibrils comprises performing the fibril formation and mineralisation in one step. An Independent claim is also included for the manufacture of a collagen/calcium phosphate by embedding the produced mineralised collagen fibrils in a calcium phosphate cement consisting of calcium phosphates, e.g. tetracalcium phosphate, calcium hydrogen phosphate, calcium hydroxylapatite, calcium dihydrogen phosphate and/or calcium carbonate, sodium phosphates and/or their mixtures, using a collagen:CaP weight ratio of 1:1-200.
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