1-(5-SULFONYL-PYRIDIN-2-YL)-5-(METHYLIDENE-CYCLOALKYLMETHOXY)-1H-PYRAZOLE-4-CARBONITRILE DERIVATIVES AND OTHER COMPOUNDS AS CYCLOOXYGENASE INHIBITORS FOR THE TREATMENT OF ARTHRITIS, NEURODEGENERATION AND COLON CANCER

摘要

The present invention relates to 5-{alkylidene-cycloalkyl)-pyrazoles and 5-(alkylidene-heterocyclyl)-pyrazoles of the formula I, wherein the ring of the formula (R5)-A-{SO¿mR?4), m, B, ring G, R1 through R7 are as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.